CLIA| CLSI| CAP| FDA 21 CFR Part 11

CLIA & CAP Laboratory Validation
Software — Made Simple

Cloud-based validation software for clinical laboratories. Run CLIA-compliant studies, generate audit-ready reports, and manage your entire QA workflow — from any device.

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Not Just a Calculator

Three Complete Systems. One Platform. One Price.

ValidToolsLab isn't a single tool — it's three systems your lab would otherwise need to buy separately, working together under one login.

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Method Validation & Statistics

35+ CLIA/CAP/CLSI-compliant modules — Precision, Accuracy, Linearity, Method Comparison, Interference, Carryover, Molecular, Blood Bank, and more.

The Core Validation Engine
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Equipment & Reagent Management

Daily/weekly/monthly instrument maintenance per manufacturer specs, reagent lot inventory, expiration alerts, and lot-change verification tracking.

Day-to-Day Operations
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Quality Management Suite

Document control (SOPs), CAPA tracking, inspection findings, staff credentials, competency assessment, PT/EQA tracking, staff scheduling, and Six Sigma benchmarking.

Full Compliance Coverage

✓ All three systems included in every plan — no add-ons, no upsells, no separate logins.

Built-in Quality Management

Six Sigma Quality Parameters — Automatic on Every Report

Every quantitative module automatically calculates your method's Six Sigma performance using your TEa (Total Allowable Error) from CLIA 2024 or Biological Variation tables — no extra steps required.

TEa
Total Allowable Error
CLIA 2024 & BV Milan 2023
SEa
Systematic Allowable Error
= TEa / 2
REa
Random Allowable Error
= TEa / 2
σ
Six Sigma
= (TEa − |Bias|) / CV
TE
Total Error
= |Bias| + 1.65×CV
QC
Strategy
Auto-recommended
Westgard rules per σ
σ ≥ 6 · World Class σ ≥ 5 · Excellent σ ≥ 4 · Good σ ≥ 3 · Marginal σ < 3 · Poor — Review
46 Modules — Quantitative, Qualitative, Semiquantitative & Tools
📈 Quantitative Verification Modules
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Method Comparison

Deming & Passing-Bablok regression · Bland-Altman · Tukey outliers · TEa cone · σ Sigma.

CLSI EP09-A3
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Precision

Within/between-run SD & CV · 95% CI for SD · Tukey outliers · Precision Goal Chart · Run Chart.

CLSI EP05-A3
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Linearity / AMR

R² · SEE · SD & CV per level · %Recovery · TEa cone · Non-linearity test.

CLSI EP06-A

Calibration Verification

SEE · SD per level · 95% CI for bias · Tukey outliers · TEa proximity cone.

CLIA §493.1255

Carryover — Broughton

C% · SD of lows · t-test significance · Sequence plot with ±2SD bands.

Broughton / EP47
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Carryover — CLSI EP47

Mean baseline vs contaminated post-high samples · Statistical significance.

CLSI EP47
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Carryover — H26 Hematology

Multi-parameter hematology carryover · SD of lows · t-test.

CLSI H26-A2
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Lot-to-Lot / Method Comparison

Deming regression · Bland-Altman · Tukey · 95% CI for bias · TEa goals · σ Sigma.

CLIA §493.1256
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Stability Verification

Drift % per timepoint · Linear trend analysis · SD of drift · Expiry prediction.

CLSI EP25-A
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Multi-Point Correlation

Pearson matrix · Deming per pair · Bland-Altman · Tukey · TEa goals · σ Sigma.

CLSI EP09-A3
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Total Error Assessment

TE = |Bias| + 1.65×CV vs TEa · Six Sigma per QC level · CLIA & BV tables auto-fill.

CLSI C24-A4
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Accuracy / Bias Verification

%Bias vs known value · 95% CI · %Recovery · TEa/SEa · Six Sigma · PT/EQA/CRM/NIST.

CLIA §493.1253
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Matrix Effect & Commutability

Commutability · 95% Prediction Interval · Deming · QC material validation vs native patient samples.

CLSI EP14-A3
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Interference Evaluation

Dose-Response (EP07 §6) · Paired Difference (EP07 §7) · Hemolysis · Lipemia · Icterus · Critical threshold.

CLSI EP07-A3
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QC Peer Instrument Monitoring

Z-score across 20+ instruments · Drift detection · Run chart · Heatmap · Monthly comparison.

CLIA §493.1256
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Reference Interval Verification

% outside proposed RI · D'Agostino normality test · 90% CI for RI limits · Histogram.

CLSI EP28-A3c
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Dilution Linearity

R² · SEE · %Recovery per step · Tukey outliers · TEa cone · Expiry prediction.

CLSI EP34-A
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Multi-Point Calibration

Multi-level calibration curve verification · Regression per level.

CLSI EP06
✅ Qualitative Modules
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Qualitative Method Comparison

PPA · NPA · PPV · NPV (95% Wilson CI) · FPR/FNR · Cohen's Kappa · Matrix heatmap.

CLSI EP12-A2
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Qualitative Precision

Reproducibility for Pos/Neg assays · % agreement with 95% CI.

CLSI EP12
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Qualitative Carryover

Cross-contamination detection for PCR & rapid tests.

Qualitative
⚖️ Semiquantitative & Serology
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Semiquantitative Precision

Reproducibility for graded scales (Neg/Trace/1+/2+/3+/4+) · 95% CI · Distribution chart.

CLSI EP15
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Semiquantitative Correlation

Compare two methods on graded scales · Weighted kappa · 95% CI · Per-grade chart.

CLSI EP26
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Titer Verification

RPR, VDRL, ANA — dilution series comparison (±1 step).

CLSI EP26
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Cross Lot-to-Lot

Serology lot change: QC old/new vs reagent old/new. Quantitative & qualitative.

CLSI EP26
🛠️ Tools
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PDF → CSV Converter

Extract tables from analyzer reports automatically.

Tool
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CSV Cleaner

Preview, remove columns, and download clean CSV files.

Tool
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CSV Merger

Combine two CSV files — auto-maps columns, remap or skip any field.

Tool
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Dilution Calculator

C₁V₁ = C₂V₂ · Serial dilution series · Linearity verification built-in.

Tool
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Competency Assessment

6 required CLIA elements per analyst/test · Due date tracking · Overdue alerts.

CLIA §493.1451
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PT/EQA Tracker

Grade PT events · SDI calculation · Unsuccessful pattern detection across events.

CLIA §493.801-865
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CAPA Tracker

Corrective/Preventive Action cases · Root cause · Effectiveness verification · Full lifecycle.

CAP GEN.20376
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Master Validation Plan

Consolidate every study for an instrument into one inspection-ready package · Gap checklist.

Tool
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Sigma Trending Dashboard

Month-by-month Six Sigma trend by instrument, department, or analyte · Improving vs declining.

Tool
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Molecular/PCR Validation

Limit of Detection & Quantitation · Hit-rate analysis · Cross-reactivity panel.

CLSI EP17-A2
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Blood Bank Verification

ABO/Rh typing concordance · Antibody screen sensitivity · Patient-safety-critical.

AABB Standards

Real Reports, Before You Request a Demo

These are actual reports generated by ValidToolsLab's calculation engine, using sample data — the exact PDF-ready format your director will see. Show them to your lab director before requesting access.

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Precision Study Report

CLSI EP05-A3 precision evaluation — SD/CV, 95% confidence intervals, Six Sigma, digital signatures and director approval, fully formatted.

View Sample Report →
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Method Comparison Report

CLSI EP09-A3 method/lot comparison — Deming regression, Bland-Altman, Six Sigma, and full inspection-ready documentation.

View Sample Report →
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Six Sigma / QC Rules Report

Automatic Six Sigma calculation per QC level with a data-driven Westgard rule recommendation — exactly what your director needs to justify your QC design.

View Sample Report →

Sample data only — not a real patient or laboratory result.

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Free Regulatory Validation Kit

Download our complete IQ/OQ/PQ validation package — includes a print-ready manual and 22 reference CSV templates designed for CLIA, CAP, and Joint Commission inspections.

✓ IQ/OQ/PQ Manual (HTML → PDF) ✓ 22 Reference CSV Templates ✓ CLSI EP05, EP06, EP07, EP09, EP17 ✓ CLIA '88 & CAP Compliant ✓ 100% Free — No signup required
⬇️ Download Free Validation Kit

ZIP file · 6.8 KB · No email required

Built For

Who Uses ValidToolsLab?

Any clinical laboratory that needs to meet CLIA, CAP, or CLSI validation requirements — without spending hours in Excel.

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Hospital Core Labs
CAP-accredited labs managing multi-instrument fleets and annual verification cycles.
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Reference Laboratories
High-volume labs requiring consistent, reproducible validation documentation across sites.
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Physician Office Labs
CLIA-certified labs that need affordable, easy-to-use validation without a dedicated quality team.
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Specialty & Genetics Labs
Molecular, microbiology, and genetics labs verifying qualitative and semiquantitative methods.

Built to Pass Your IT Security Review

The most common reason a lab validation tool stalls before purchase is a security review. Here's exactly what your IT department will find when they look — before they even have to ask.

🔒 TLS / HTTPS Encryption 🚫 Zero Patient Data 🗄️ Encrypted Database 🧾 Immutable Audit Trail 🔑 Role-Based Access
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No Patient Data, Ever

ValidToolsLab stores instrument QC readings, reagent lots, and validation statistics — never patient results, MRNs, or other Protected Health Information. Most HIPAA-scoped reviews can be simplified accordingly.

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Encrypted in Transit & at Rest

Every connection runs over HTTPS/TLS. Data lives in a managed PostgreSQL database with encryption at rest and automated backups — no data is ever stored on a local machine.

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Role & Department-Scoped Access

Staff only see what their role and department allow. Access defaults to deny — a user with no assignment sees nothing until an admin explicitly grants it.

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Tamper-Evident Audit Trail

Every login, edit, approval, and signature is logged with user, timestamp, and IP address in a hash-chained record built to surface tampering — ready for a CAP or CLIA inspector.

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Digital Signatures & Director Approval

Every validation report requires an analyst signature and a director sign-off before it's finalized — a documented chain of accountability for every result.

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Isolated Per Organization

Each lab's data is logically separated from every other company on the platform. There is no shared visibility across organizations.

Have a security questionnaire, or want to walk your IT team through our architecture? Email sales@validtoolslab.com — we're happy to schedule a call.

Everything your lab needs — nothing it doesn't

The only cloud-based validation platform built specifically for clinical laboratories with a full director approval workflow and digital signatures.

Feature ValidToolsLab Legacy Desktop Tools Excel-Based Tools
Cloud-based — access from any device ❌ Windows only ❌ Windows + Excel
Multi-user with role-based access ❌ Single user ❌ Single user
Director approval workflow
Digital signatures (analyst + director)
Immutable audit trail
Qualitative & semiquantitative modules ✅ 6 modules ⚠️ Limited ⚠️ Limited
3 carryover protocols (Broughton/EP47/H26) ⚠️ Partial
Mobile app (iPhone & Android PWA)
Email notifications on report submission
Regulatory context page per module
Instrument model management
CSV upload + manual data entry ⚠️ Manual only ⚠️ Copy-paste
5-day free trial — no credit card ❌ Demo only ⚠️ 14-day trial

Choose the Plan That Fits Your Lab

All plans include all 3 systems — Validation, Equipment/Reagent Management & Quality Suite · Annual billing · Cancel anytime

Starter
Perfect for small labs
$865/year
  • ✓ 2 users
  • ✓ All 3 systems (Validation, Equipment/Reagent, Quality Suite)
  • ✓ Digital signatures
  • ✓ Unlimited reports
  • ✓ 5-day free trial
Get Started →
Most Popular
Professional
For growing teams
$1,440/year
  • ✓ 5 users
  • ✓ All 3 systems (Validation, Equipment/Reagent, Quality Suite)
  • ✓ Digital signatures
  • ✓ Unlimited reports
  • ✓ 5-day free trial
Get Started →
Enterprise
For full-scale labs
$2,880/year
  • ✓ 15 users
  • ✓ All 3 systems (Validation, Equipment/Reagent, Quality Suite)
  • ✓ Digital signatures
  • ✓ Unlimited reports
  • ✓ 5-day free trial
Get Started →

Not ready to subscribe? Try it free first.

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No credit card required

White-Glove Option

Don't Have Time to Run It Yourself?

ValidToolsLab Concierge — send us your data, and a licensed Medical Laboratory Technologist runs the study and sends back a signed, director-ready report. No software to learn.

Request Concierge Service →

Contact us for pricing — quoted same day.